Hyaluronic acid fillers:

trust Foliage’s technological innovation

Produced in its production site of over 5,000 square meters, certified and equipped with state-of-the-art advanced technologies, Foliage is able to offer its customers a completely Made in Italy product, of superior quality and respectful of the highest standards.

Leader among filler manufacturers

Foliage line of facial and lip injectables stems from the extensive experience of Phitogen Holding S.p.A., a leading manufacturer of fillers for aesthetic medicine and devices based on pure hyaluronic acid of non-animal origin, produced by fermentation from streptococcus equi.

Safety and superior quality

Raw material processing, managed step by step by highly qualified personnel, takes place in a controlled environment with zero levels of endotoxins, performing purification processes with residue limits on finished products below instrumental detection parameters.

It is thanks to a production system based on environmentally sustainable approaches, certified safety protocols and the use of advanced technologies that the quality of hyaluronic acid injections can be constantly raised, minimising the risk of external contamination and operating in full compliance with the strict quality parameters required by end users.

2CORE technology: the future is already here

Foliage fillers require less chemical crosslinking agents (BDDE) and are therefore particularly malleable, homogeneous and integrable with skin tissue.

The products’ unique biophysical profile is due to the 2CORE technology used during processing, which is based on the sequential combination of two production steps:

1. Conservative Reticulation

In the first phase, the aim is to reduce the amount of chemical agent BDDE.

The method used involves mixing the components at low temperatures for long periods, in order to control the level of cross-linking.

This process also achieves another fundamental result: low temperatures prevent depolymerisation of hyaluronic acid and keep its biological and viscoelastic properties intact.

2. Particle Size Control & Reduction

The second stage, which involves high-pressure sieving of the raw material particles into microspheres from 1 to 20 microns, affects the homogeneity of the gel, thus modulating tissue integration and distribution, fluidity and consequently product handling.

Lastly, it should be emphasised that, in the wake of the qualitative excellence that distinguishes Phitogen’s production of hyaluronic acid-based medical devices, all injectables in the Foliage line:

  • are developed in accordance with the specific procedures codified in the ISO 9001, ISO 13485 and ISO 14001 quality management system.
  • meet the quality and safety requirements necessary to release finished products onto the market.

Our distributors

If you want to discover our products firsthand, and learn more about features and functionality, we recommend that you contact our distributors around the world.

Foliage is the result of 20 years' experience of Phitogen Holding S.p.A. - a leading group in the production of hyaluronic acid-based injectables. Foliage distributes a complete range of high-performing intradermal products.

Via Valtellina, 21
San Benedetto del Tronto (AP)
63074 – Italy

+39 0735 762020