Research & Development respecting nature
The entire Foliage line is produced by Phitogen Holding spa, a leader in the filler market, which has patented innovative technology and environmentally sustainable production processes. Phitogen has been supplying important national and international brands for years, offering its business customers complete support for the implementation of high-end and 100% Made in Italy hyaluronic acid-based filler lines.
The Hyaluronic Acid extraction process takes place within a certified production site of over 5,000 square meters, equipped with a latest generation clean room, which allows to obtain a raw material free of nucleic acids and residual proteins, guaranteeing quality standards of excellence and maximum safety.
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1
1.
Raw materials
Ultra-pure hyaluronic acid, which at this stage is still in powder state, is placed in special containers where it is weighed, sealed and taken to the sterile liquid filling department where the more viscous hyaluronic acid solution is prepared.
2
2.
Cross-Linking
In this first stage, ultra-pure Hyaluronic Acid with no nucleic acids and no residual proteins is mixed with the cross-linking agent BDDE at low temperature over a long period of time. This unique manufacturing process, known as cross-linking, preserves the specific visco-elastic properties of Hyaluronic Acid, and above all allows smaller quantities of the chemical cross-linking agent BDDE to be used, resulting in a superior quality product with a very high degree of biocompatibility.
3
3.
Purification
The mixture is purified using a dialysis process via WFI (water for injection). This process eliminates any residual BDDE molecules, ensuring a product with a high level of purity and low toxicity.
4
4.
Mixing
The product is mixed with a buffered solution to provide a neutral pH value.
5
5.
Filling
The resulting mixture is placed in the tank of a filling machine with lack of oxygen, where it will remain for several hours while waiting for the lab tests to prove that it meets the quality and purity requirements. Once checked, the product is ready to be filled using an automatic filling machine.
6
6.
Sterilisation
The pre-filled syringes are then autoclaved, using moist heat for 15 minutes at 121 degrees Celsius. Once the sterilisation process is complete, the syringes are left on stand-by while waiting for the results of the quality control tests.
7
7.
Quality control and product release
At this stage, final tests are carried out to certify that the quality and safety requirements for the release of the finished product have been met: – Extrudability and pH control – External tests at certified laboratories – Sterility and LAL test – and Visual inspection.
8
8.
Packaging
At this stage, the syringe is placed in a thermoformed blister pack sealed with medical paper and inserted into the packaging. Finally, the product is packed and transferred to the warehouse where it will be stored at storage temperatures while awaiting dispatch to the customer.
1
1.
Raw materials
Ultra-pure hyaluronic acid, which at this stage is still in powder state, is placed in special containers where it is weighed, sealed and taken to the sterile liquid filling department where the more viscous hyaluronic acid solution is prepared.
2
2.
Cross-Linking
In this first stage, ultra-pure Hyaluronic Acid with no nucleic acids and no residual proteins is mixed with the cross-linking agent BDDE at low temperature over a long period of time. This unique manufacturing process, known as cross-linking, preserves the specific visco-elastic properties of Hyaluronic Acid, and above all allows smaller quantities of the chemical cross-linking agent BDDE to be used, resulting in a superior quality product with a very high degree of biocompatibility.
3
3.
Purification
The mixture is purified using a dialysis process via WFI (water for injection). This process eliminates any residual BDDE molecules, ensuring a product with a high level of purity and low toxicity.
4
4.
Mixing
The product is mixed with a buffered solution to provide a neutral pH value.
5
5.
Filling
The resulting mixture is placed in the tank of a filling machine with lack of oxygen, where it will remain for several hours while waiting for the lab tests to prove that it meets the quality and purity requirements. Once checked, the product is ready to be filled using an automatic filling machine.
6
6.
Sterilisation
The pre-filled syringes are then autoclaved, using moist heat for 15 minutes at 121 degrees Celsius. Once the sterilisation process is complete, the syringes are left on stand-by while waiting for the results of the quality control tests.
7
7.
Quality control and product release
At this stage, final tests are carried out to certify that the quality and safety requirements for the release of the finished product have been met: – Extrudability and pH control – External tests at certified laboratories – Sterility and LAL test – and Visual inspection.
8
8.
Packaging
At this stage, the syringe is placed in a thermoformed blister pack sealed with medical paper and inserted into the packaging. Finally, the product is packed and transferred to the warehouse where it will be stored at storage temperatures while awaiting dispatch to the customer.
Based upon these premises, Foliage – a complete range of injectables based on pure Hyaluronic Acid – is developed and produced under an exclusive patent by Phitogen Beauty Labs.
Our products
Discover the full range of our aesthetic medicine solutions for natural rejuvenation.
An innovative monophasic gel based on biodegradable cross-linked hyaluronic acid.
Monophasic viscoelastic filler with ultra pure cross-linked hyaluronic acid.
High-viscosity volume-boosting filler with pure cross-linked hyaluronic acid of non-animal origin.
Single-phase gel containing sterile, resorbable cross-linked hyaluronic acid.
Bio-revititalising gel based on pure, biocompatible hyaluronic acid of non-animal origin.
Nature is beauty
The entire Foliage Filler line is inspired by the cyclical changes that have always characterized both nature and man: a “natural” revolution that draws its most disruptive strength from the passage of time.
Supporting a concept of care and aesthetic harmony inspired by biological becoming and aimed at a ‘Cyclic Maintenance of Beauty’: these are Foliage’s values, this is the behind its products.
Foliage hyaluronic acid fillers aim to preserve and improve the physiological well-being of the skin, without distorting the original features and without pursuing stilted results.
Foliage makes it possible to cope naturally with ‘aesthetic time’, through the use of high-end organic-based revitalising products that achieve progressive, natural, and longer-lasting results.
Made in Italy
production
Full guarantee of an entirely Italian production, in which each stage is managed and checked by in-house laboratories and specialised professionals.
2 CORE
technology
The processing technology is based on the sequential combination of two production steps: Conservative Reticulation and Particle Size Control & Reduction.
Our distributors
If you would like to discover our products live, and learn more about their features and functionality, please contact our worldwide distributors.
Foliage is the result of 20 years' experience of Phitogen Holding S.p.A. - a leading group in the production of hyaluronic acid-based injectables. Foliage distributes a complete range of high-performing intradermal products.
CONTACT US
Via Valtellina, 21
San Benedetto del Tronto (AP)
63074 – Italy
